Tissue expression
Cell line expression
Protein structure
TRIM68
Tripartite motif containing 68FLJ10369, RNF137, SS-56
This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a ""really interesting new gene"" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Top validated antibodies |
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antibodies-online | ABIN1109337 | 1 references | Polyclonal |
WB
IHC |
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LSBio | LS-C431149 | Polyclonal |
WB
IHC |
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Biorbyt | orb455352 | Polyclonal |
WB
EL
ICC
IHC |
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St John's Laboratory | STJ96447 | Polyclonal |
WB
EL
ICC
IHC |
||
Affinity Biosciences | DF10055 | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider