Tissue expression
Cell line expression
Protein structure
VKORC1
Vitamin K epoxide reductase complex subunit 1VKCFD2
This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Top validated antibodies |
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LSBio | ![]() |
Polyclonal |
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Invitrogen Antibodies | ![]() |
1 references | Polyclonal |
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GeneTex | ![]() |
Polyclonal |
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Boster Biological Technology | ![]() |
Polyclonal |
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antibodies-online | ![]() |
1 references | Polyclonal |
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