CDC42EP5

Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]

Description

CDC42 effector protein 5

Tissue specificity

Tissue enhanced (prostate)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

19 (54465026 - 54473296)

Ensembl ID

ENSG00000167617  (ver. 103.38)

Orthologs

Mouse Cdc42ep5: ENSMUSG00000063838

UniProt

Q6NZY7

neXtProt

NX_Q6NZY7

Human splice variants
Mouse splice variants

Protein structure