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Protein structure
NDUFV1
NADH:ubiquinone oxidoreductase core subunit V1CI-51K
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2009]
Top validated antibodies |
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| Proteintech Group |  11238-1-AP |
41 references | Polyclonal |
WB
EL
IP
IHC
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| Invitrogen Antibodies | PA5-21426 |
1 references | Polyclonal |
WB
IHC
OA
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| Novus Biologicals | H00004723-M01 |
1 references | Monoclonal |
WB
EL
BN
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| GeneTex | GTX102209 |
2 references | Polyclonal |
WB
IHC
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| NovoPro Bioscience Inc. | 113086 |
Polyclonal |
WB
EL
IP
IHC
|
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