ABCA3

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]

Description

ATP binding cassette subfamily A member 3

Tissue specificity

Tissue enhanced (lung)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Membrane

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Potential drug targets
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

16 (2275881 - 2340746)

Ensembl ID

ENSG00000167972  (ver. 103.38)

Orthologs

Mouse Abca3: ENSMUSG00000024130

UniProt

Q99758

neXtProt

NX_Q99758

Human splice variants
Mouse splice variants

Protein structure