REPS2

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

RALBP1 associated Eps domain containing 2

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (16946658 - 17153272)

Ensembl ID

ENSG00000169891  (ver. 103.38)

Orthologs

Mouse Reps2: ENSMUSG00000040855

UniProt

Q8NFH8

neXtProt

NX_Q8NFH8

Human splice variants
Mouse splice variants

Protein structure