ATP6V0E2

Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]). [supplied by OMIM, Mar 2008]

Description

ATPase H+ transporting V0 subunit e2

Tissue specificity

Tissue enhanced (brain)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

7 (149872968 - 149891204)

Ensembl ID

ENSG00000171130  (ver. 103.38)

Orthologs

Mouse Atp6v0e2: ENSMUSG00000039347

UniProt

Q8NHE4

neXtProt

NX_Q8NHE4

Human splice variants
Mouse splice variants

Protein structure