Tissue expression
Cell line expression
Protein structure
CLEC7A
C-type lectin domain containing 7ACD369, CLECSF12, dectin-1, hDectin-1, SCARE2
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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GeneTex | ![]() |
3 references | Monoclonal |
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Invitrogen Antibodies | ![]() |
1 references | Polyclonal |
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R&D Systems | ![]() |
21 references | Monoclonal |
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Novus Biologicals | ![]() |
22 references | Monoclonal |
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antibodies-online | ![]() |
4 references | Polyclonal |
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