Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
ADCY6
Adenylate cyclase 6AC6
This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]
Top validated antibodies |
|||||
| GeneTex |  GTX47798 |
4 references | Polyclonal |
WB
EL
ICC
IHC
|
|
| Proteintech Group | 14616-1-AP |
5 references | Polyclonal |
WB
EL
IP
|
|
| Santa Cruz Biotechnology | sc-590 |
6 references | Polyclonal (Antigen purified) |
WB
IHC
|
|
| Biorbyt | orb5794 |
Polyclonal |
WB
EL
ICC
IHC
|
||
| Invitrogen Antibodies | PA5-101284 |
Polyclonal |
WB
ICC
IHC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider