CNIH2

The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Description

Cornichon family AMPA receptor auxiliary protein 2

Tissue specificity

Tissue enriched (brain)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

11 (66278175 - 66285301)

Ensembl ID

ENSG00000174871  (ver. 103.38)

Orthologs

Mouse Cnih2: ENSMUSG00000024873

UniProt

Q6PI25

neXtProt

NX_Q6PI25

Human splice variants
Mouse splice variants

Protein structure