LSM1

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

Description

LSM1 homolog, mRNA degradation associated

Tissue specificity

Low tissue specificity

Subcell location

Cytosol, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (38163335 - 38176730)

Ensembl ID

ENSG00000175324  (ver. 103.38)

Orthologs

Mouse Lsm1: ENSMUSG00000037296

UniProt

O15116

neXtProt

NX_O15116

Human splice variants
Mouse splice variants

Protein structure