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Cell line expression
Protein structure
PTPN2
Protein tyrosine phosphatase non-receptor type 2PTPT, TC-PTP, TCELLPTP, TCPTP
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Top validated antibodies |
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| Proteintech Group |  11214-1-AP |
12 references | Polyclonal |
WB
EL
IP
IHC
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| Atlas Antibodies | HPA015004 |
Polyclonal |
WB
ICC
IHC
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| Invitrogen Antibodies | PA5-80959 |
Polyclonal |
WB
EL
ICC
IP
OA
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| NovoPro Bioscience Inc. | 114318 |
Polyclonal |
WB
EL
IP
IHC
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| FineTest Biotech | FNab06935 |
Polyclonal |
WB
EL
ICC
IHC
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