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Protein structure
A2M
Alpha-2-macroglobulinCPAMD5, FWP007, S863-7
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Top validated antibodies |
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| Proteintech Group |  13545-1-AP |
2 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 13545-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| R&D Systems | AF1938 |
2 references | Polyclonal |
WB
ICC
IP
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| NovoPro Bioscience Inc. | 107877 |
Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | AF1938 |
2 references | Polyclonal |
WB
ICC
IP
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