Tissue expression
Cell line expression
Protein structure
TGIF1
TGFB induced factor homeobox 1HPE4, TGIF
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Top validated antibodies |
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Santa Cruz Biotechnology | sc-17800 | 3 references | Monoclonal |
WB
IHC |
|
Cusabio Biotech Co., Ltd | CSB-PA623005LA01HU | Polyclonal |
WB
EL
ICC
IHC |
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LSBio | LS-C500893 | Polyclonal |
WB
EL
ICC
IHC |
||
Biorbyt | orb2215055 | Polyclonal |
WB
EL
ICC
IHC |
||
NSJ Bioreagents | RQ7442 | Polyclonal |
WB
EL
FC
|
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Supportive data in Antibodypedia
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Recommended by provider