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Protein structure
F2
Coagulation factor II, thrombinThis gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]
Top validated antibodies |
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| Boster Biological Technology |  A00044 |
1 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| Proteintech Group | 24295-1-AP |
3 references | Polyclonal |
WB
EL
ICC
IP
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| Novus Biologicals | H00002147-M01 |
Monoclonal |
WB
EL
IP
BN
PLA
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| Abnova Corporation | H00002147-M01 |
Monoclonal |
WB
EL
IP
PLA
|
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| Invitrogen Antibodies | 24295-1-AP |
Polyclonal |
WB
ICC
IP
OA
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