SYNM

The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Synemin

Tissue specificity

Tissue enhanced (intestine, skeletal muscle, urinary bladder)

Subcell location

Intermediate filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (99098217 - 99135593)

Ensembl ID

ENSG00000182253  (ver. 103.38)

Orthologs

Mouse Synm: ENSMUSG00000030554

UniProt

O15061

neXtProt

NX_O15061

Human splice variants
Mouse splice variants

Protein structure