Tissue expression
Cell line expression
Protein structure
SLC8A1
Solute carrier family 8 member A1NCX1
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation. [supplied by OMIM, Apr 2004]
Top validated antibodies |
|||||
Invitrogen Antibodies | MA3-926 | 91 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA |
|
GeneTex | GTX80928 | 1 references | Polyclonal |
WB
IHC
FC
|
|
Proteintech Group | 55075-1-AP | 3 references | Polyclonal |
WB
EL
IP
|
|
antibodies-online | ABIN2029680 | Polyclonal |
WB
IHC
FC
|
||
Abgent | AP8939c | Polyclonal |
WB
IHC
FC
|
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