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Protein structure
WT1
WT1 transcription factorAWT1, GUD, NPHS4, WAGR, WIT-2
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
Top validated antibodies |
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| Proteintech Group |  12609-1-AP |
37 references | Polyclonal |
WB
EL
ICC
IP
FC
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| Invitrogen Antibodies | MA5-32215 |
1 references | Monoclonal |
WB
ICC
IHC
FC
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| Novus Biologicals | NB110-60011 |
6 references | Monoclonal |
WB
ICC
IP
IHC
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| antibodies-online | ABIN2845304 |
5 references | Polyclonal |
WB
ICC
IHC
FC
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| Boster Biological Technology | M00199-1 |
3 references | Monoclonal |
WB
ICC
IHC
FC
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