Tissue expression
Cell line expression
Protein structure
SIVA1
SIVA1 apoptosis inducing factorCD27BP, SIVA, Siva-1, Siva-2
This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Top validated antibodies |
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antibodies-online | ![]() |
4 references | Polyclonal |
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GeneTex | ![]() |
Polyclonal |
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Invitrogen Antibodies | ![]() |
Monoclonal |
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OriGene | ![]() |
Monoclonal |
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Novus Biologicals | ![]() |
Monoclonal |
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