Tissue expression
Cell line expression
Protein structure
TNFRSF18
TNF receptor superfamily member 18AITR, CD357, GITR
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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Invitrogen Antibodies | A700-068 | Monoclonal |
WB
ICC
IP
IHC
FC
OA |
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R&D Systems | AF689 | 2 references | Polyclonal |
WB
IHC
FC
BN |
|
Novus Biologicals | AF689 | 2 references | Polyclonal |
WB
IHC
FC
BN |
|
Cell Signaling Technology, Inc | 10419 | Monoclonal |
WB
ICC
IP
IHC
FC
|
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Biorbyt | orb1519832 | Recombinant |
WB
ICC
IP
IHC
FC
|
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Supportive data in Antibodypedia
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Recommended by provider