S100A13

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

S100 calcium binding protein A13

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Plasma membrane, Cytosol

Predicted location

Intracellular, Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (153618787 - 153631360)

Ensembl ID

ENSG00000189171  (ver. 103.38)

Orthologs

Mouse S100a13: ENSMUSG00000042312

UniProt

Q99584

neXtProt

NX_Q99584

Human splice variants
Mouse splice variants

Protein structure