SPANXD

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]

Description

SPANX family member D

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

X (141697411 - 141698739)

Ensembl ID

ENSG00000196406  (ver. 103.38)

Orthologs

-

UniProt

Q9BXN6

neXtProt

NX_Q9BXN6

Human splice variants

Protein structure