Tissue expression
Cell line expression
Protein structure
HLA-DQA1
Major histocompatibility complex, class II, DQ alpha 1CELIAC1, HLA-DQA
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Novus Biologicals | NB100-2701 | Monoclonal |
WB
EL
IP
IHC
FC
RA |
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Proteintech Group | 16918-1-AP | 3 references | Polyclonal |
WB
EL
IHC
FC |
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antibodies-online | ABIN952750 | 3 references | Polyclonal |
WB
EL
FC
|
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Invitrogen Antibodies | 16918-1-AP | Polyclonal |
WB
IHC
FC
|
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NSJ Bioreagents | F54763 | Polyclonal |
WB
ICC
FC
|
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