Tissue expression
Cell line expression
Protein structure
MVB12B
Multivesicular body subunit 12BC9orf28, FAM125B, FLJ00001
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Top validated antibodies |
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Atlas Antibodies | ![]() |
Polyclonal |
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antibodies-online | ![]() |
Polyclonal |
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Novus Biologicals | ![]() |
Polyclonal |
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Acris Antibodies GmbH | ![]() |
Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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