Tissue expression
Cell line expression
Protein structure

TPSB2

Tryptase beta 2
 
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
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158 antibodies from 22 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Biorbyt
67 antibodies
Novus Biologicals
4 antibodies
Cusabio Biotech Co., Ltd
6 antibodies
R&D Systems
2 antibodies
Invitrogen Antibodies
5 antibodies
St John's Laboratory
2 antibodies
Atlas Antibodies
1 antibody
Santa Cruz Biotechnology
1 antibody
antibodies-online
28 antibodies
MyBioSource
4 antibodies
OriGene
2 antibodies
Creative Diagnostics
2 antibodies
GeneTex
1 antibody
Abbexa
7 antibodies
GenWay
2 antibodies
Creative Biolabs
6 antibodies
Proteintech Group
1 antibody
Enzo Life Sciences
1 antibody
Sino Biological Inc.
1 antibody
Abnova Corporation
2 antibodies
MilliporeSigma / Merck KGaA
1 antibody