SVIL

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]

Description

Supervillin

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Subcell location

Plasma membrane, Actin filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (29457338 - 29736959)

Ensembl ID

ENSG00000197321  (ver. 103.38)

Orthologs

Mouse Svil: ENSMUSG00000024236

UniProt

O95425

neXtProt

NX_O95425

Human splice variants
Mouse splice variants

Protein structure