Tissue expression
Cell line expression
Protein structure
SPN
SialophorinCD43, GPL115, LSN
This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]
Top validated antibodies |
|||||
Novus Biologicals | NBP2-15190-0.1mg | Monoclonal |
WB
EL
ICC
IP
IHC
FC |
||
Invitrogen Antibodies | 14-0439-82 | 11 references | Monoclonal |
WB
IHC
FC
OA |
|
NSJ Bioreagents | V3651 | Monoclonal |
WB
ICC
IHC
FC
OA
|
||
GeneTex | GTX79932 | Monoclonal |
WB
IP
IHC
FC
FA
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider