Tissue expression
Cell line expression
Protein structure
PSAP
ProsaposinGLBA, SAP1, SAP2
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Top validated antibodies |
|||||
antibodies-online | ABIN1098150 | 2 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
|
Proteintech Group | 10801-1-AP | 20 references | Polyclonal |
WB
EL
ICC
IHC |
|
OriGene | AM39077PU-S | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
Acris Antibodies GmbH | AM39077PU-S | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
GeneTex | GTX60673 | Monoclonal |
WB
EL
ICC
IHC
FC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider