Tissue expression
Cell line expression
Protein structure
CD2AP
CD2 associated proteinCMS
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | PA5-28391 | 1 references | Polyclonal |
WB
ICC
IHC
OA |
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Proteintech Group | 51046-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IP |
|
Boster Biological Technology | A01756-2 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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GeneTex | GTX106235 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
Atlas Antibodies | HPA003267 | Polyclonal |
WB
ICC
IHC
|
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider