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Cell line expression
Protein structure
PLN
PhospholambanCMD1P, PLB
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Top validated antibodies |
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| Invitrogen Antibodies |  MA3-922 |
176 references | Monoclonal |
WB
ICC
IP
IHC
OA
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| GeneTex | GTX22865 |
1 references | Monoclonal |
WB
ICC
IP
IHC
BN
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| antibodies-online | ABIN152737 |
5 references | Monoclonal |
WB
ICC
IP
IHC
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| Novus Biologicals | NBP1-49852 |
1 references | Polyclonal |
WB
EL
IHC
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| Badrilla Ltd | A010-12 |
106 references | Polyclonal |
WB
EL
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