KCNIP4

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel interacting protein 4

Tissue specificity

Tissue enhanced (brain, retina)

Subcell location

Vesicles

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

4 (20728606 - 21948772)

Ensembl ID

ENSG00000185774  (ver. 103.38)

Orthologs

Mouse Kcnip4: ENSMUSG00000029088

UniProt

Q6PIL6

neXtProt

NX_Q6PIL6

Human splice variants
Mouse splice variants

Protein structure