GRM7

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Description

Glutamate metabotropic receptor 7

Tissue specificity

Tissue enhanced (brain, parathyroid gland)

Subcell location

Cytosol

Predicted location

Intracellular, Membrane

Protein family

G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (6770001 - 7741533)

Ensembl ID

ENSG00000196277  (ver. 103.38)

Orthologs

Mouse Grm7: ENSMUSG00000056755

UniProt

Q14831

neXtProt

NX_Q14831

Human splice variants
Mouse splice variants

Protein structure