HSCB

This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

HscB mitochondrial iron-sulfur cluster cochaperone

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (28742039 - 28757515)

Ensembl ID

ENSG00000100209  (ver. 103.38)

Orthologs

Mouse Hscb: ENSMUSG00000043510

UniProt

Q8IWL3

neXtProt

NX_Q8IWL3

Human splice variants
Mouse splice variants

Protein structure