TLR1

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

Description

Toll like receptor 1

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

4 (38790677 - 38856817)

Ensembl ID

ENSG00000174125  (ver. 103.38)

Orthologs

Mouse Tlr1: ENSMUSG00000044827

UniProt

Q15399

neXtProt

NX_Q15399

Human splice variants
Mouse splice variants

Protein structure