HRH1

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

Description

Histamine receptor H1

Tissue specificity

Tissue enhanced (urinary bladder)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

3 (11137093 - 11263557)

Ensembl ID

ENSG00000196639  (ver. 103.38)

Orthologs

Mouse Hrh1: ENSMUSG00000053004

UniProt

P35367

neXtProt

NX_P35367

Human splice variants
Mouse splice variants

Protein structure