MMP25

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Description

Matrix metallopeptidase 25

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

16 (3046062 - 3060726)

Ensembl ID

ENSG00000008516  (ver. 103.38)

Orthologs

Mouse Mmp25: ENSMUSG00000023903

UniProt

Q9NPA2

neXtProt

NX_Q9NPA2

Human splice variants
Mouse splice variants

Protein structure