BS8456

antibody from Bioworld Technology, Inc
Targeting: BIRC5 API4, EPR-1, survivin
Provider product page for BS8456
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8456 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Survivin polyclonal antibody
Antibody type
Polyclonal
Antigen
Survivin; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; BIRC5; API4; IAP4
Description
Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino-terminal baculovirus IAP repeat (BIR) motif and a carboxy-terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FASmediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivinmicrotubule interactions occurs.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BIRC5 protein structure - BS8456 shown in red.