DUSP26

This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Description

Dual specificity phosphatase 26

Tissue specificity

Group enriched (skeletal muscle, tongue)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

8 (33591330 - 33600023)

Ensembl ID

ENSG00000133878  (ver. 103.38)

Orthologs

Mouse Dusp26: ENSMUSG00000039661

UniProt

Q9BV47

neXtProt

NX_Q9BV47

Human splice variants
Mouse splice variants

Protein structure