BS7890

antibody from Bioworld Technology, Inc
Targeting: PRMT2 HRMT1L1, MGC111373
Provider product page for BS7890
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7890 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PRMT2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PRMT2.
Description
PRMT2 (Protein arginine N-methyltransferase 2) is a 433 amino acid protein encoded by the human gene PRMT2. PRMT2 belongs to the protein arginine N-methyltransferase family and contains one SH3 domain. The primary function of protein methyltransferases is the post-translational methylation of arginine residues. The PRMT family of proteins contains related putative methyltransferase domains that modify chromatin and regulate cellular transcription. Some family members, PRMT1 and PRMT4, show transcriptional modulation and intracellular signaling. Through a highly conserved S-adenosylmethionine-binding domain, PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis. PRMT2 has this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, which increases nuclear IkappaB-alpha and decreases NF-kappaB DNA binding. PRMT2 also renders cells susceptible to apoptosis by cytokines or cytotoxic drugs.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PRMT2 protein structure - BS7890 shown in red.