PES1

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

Description

Pescadillo ribosomal biogenesis factor 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Nucleoli rim, Mitotic chromosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (30576625 - 30607083)

Ensembl ID

ENSG00000100029  (ver. 103.38)

Orthologs

Mouse Pes1: ENSMUSG00000020430

UniProt

O00541

neXtProt

NX_O00541

Human splice variants
Mouse splice variants

Protein structure