GPER1

This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]

Description

G protein-coupled estrogen receptor 1

Tissue specificity

Tissue enhanced (stomach)

Subcell location

Nucleoplasm, Nucleoli, Vesicles, Cytosol

Predicted location

Intracellular, Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

7 (1082208 - 1093815)

Ensembl ID

ENSG00000164850  (ver. 103.38)

Orthologs

Mouse Gper1: ENSMUSG00000053647

UniProt

Q99527

neXtProt

NX_Q99527

Human splice variants
Mouse splice variants

Protein structure