ABHD2

This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017]

Description

Abhydrolase domain containing 2, acylglycerol lipase

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (89087459 - 89202355)

Ensembl ID

ENSG00000140526  (ver. 103.38)

Orthologs

Mouse Abhd2: ENSMUSG00000039202

UniProt

P08910

neXtProt

NX_P08910

Human splice variants
Mouse splice variants

Protein structure