GZMK

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

Description

Granzyme K

Tissue specificity

Tissue enriched (lymphoid tissue)

Predicted location

Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (55024256 - 55034570)

Ensembl ID

ENSG00000113088  (ver. 103.38)

Orthologs

Mouse Gzmk: ENSMUSG00000042385

UniProt

P49863

neXtProt

NX_P49863

Human splice variants
Mouse splice variants

Protein structure