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- Antigen structure
- References [96]
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- Western blot [5]
- Immunohistochemistry [1]
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- Product number
- ABIN249446 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-PTEN Induced Putative Kinase 1 (PINK1) (AA 175-250) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- AA 175-250
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Submitted references Induction of PINK1/Parkin-Mediated Mitophagy.
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death.
Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.
Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.
MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.
CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.
Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy.
Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.
The small molecule 2-phenylethynesulfonamide induces covalent modification of p53.
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.
Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels.
Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.
BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy.
Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy.
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.
Cytoprotection against Hypoxic and/or MPP⁺ Injury: Effect of δ-Opioid Receptor Activation on Caspase 3.
Intracellular pH Modulates Autophagy and Mitophagy.
Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Pyruvate stimulates mitophagy via PINK1 stabilization.
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation.
Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.
MKK3 deletion improves mitochondrial quality.
Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.
Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy.
Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses.
PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402.
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.
Phosphorylated ubiquitin chain is the genuine Parkin receptor.
Loss of PINK1 impairs stress-induced autophagy and cell survival.
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy.
Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.
Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.
Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A.
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression.
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Upregulation of human PINK1 gene expression by NFκB signalling.
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart.
Selective escape of proteins from the mitochondria during mitophagy.
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
PINK1 is degraded through the N-end rule pathway.
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy.
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
Structural determinants of PINK1 topology and dual subcellular distribution.
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.
Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Characterization of PINK1 processing, stability, and subcellular localization.
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
The kinase domain of mitochondrial PINK1 faces the cytoplasm.
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Evaluation of the effectiveness and safety of etodolac in prolonged treatment of active osteoarthritis.
Sato S, Furuya N
Methods in molecular biology (Clifton, N.J.) 2018;1759:9-17
Methods in molecular biology (Clifton, N.J.) 2018;1759:9-17
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.
Tang C, Han H, Yan M, Zhu S, Liu J, Liu Z, He L, Tan J, Liu Y, Liu H, Sun L, Duan S, Peng Y, Liu F, Yin XM, Zhang Z, Dong Z
Autophagy 2018;14(5):880-897
Autophagy 2018;14(5):880-897
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S
Autophagy 2018;14(2):311-335
Autophagy 2018;14(2):311-335
The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death.
Yoo L, Chung KC
The Journal of biological chemistry 2018 Jan 26;293(4):1286-1297
The Journal of biological chemistry 2018 Jan 26;293(4):1286-1297
Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.
Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Apr;32(4):1880-1890
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Apr;32(4):1880-1890
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.
Martín-Maestro P, Gargini R, A Sproul A, García E, Antón LC, Noggle S, Arancio O, Avila J, García-Escudero V
Frontiers in molecular neuroscience 2017;10:291
Frontiers in molecular neuroscience 2017;10:291
Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.
Zhang C, Liu Z, Bunker E, Ramirez A, Lee S, Peng Y, Tan AC, Eckhardt SG, Chapnick DA, Liu X
The Journal of biological chemistry 2017 Sep 8;292(36):15105-15120
The Journal of biological chemistry 2017 Sep 8;292(36):15105-15120
MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.
Bartolomé A, García-Aguilar A, Asahara SI, Kido Y, Guillén C, Pajvani UB, Benito M
Molecular and cellular biology 2017 Sep 11;
Molecular and cellular biology 2017 Sep 11;
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K
Neurochemistry international 2017 Oct;109:106-116
Neurochemistry international 2017 Oct;109:106-116
Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.
Xiao B, Goh JY, Xiao L, Xian H, Lim KL, Liou YC
The Journal of biological chemistry 2017 Oct 6;292(40):16697-16708
The Journal of biological chemistry 2017 Oct 6;292(40):16697-16708
CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.
Kim H, Ham S, Jo M, Lee GH, Lee YS, Shin JH, Lee Y
International journal of molecular sciences 2017 Oct 3;18(10)
International journal of molecular sciences 2017 Oct 3;18(10)
Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy.
Wettengel J, Reautschnig P, Geisler S, Kahle PJ, Stafforst T
Nucleic acids research 2017 Mar 17;45(5):2797-2808
Nucleic acids research 2017 Mar 17;45(5):2797-2808
Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.
Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, Dudek J
Autophagy 2017 Jan 2;13(1):201-211
Autophagy 2017 Jan 2;13(1):201-211
The small molecule 2-phenylethynesulfonamide induces covalent modification of p53.
Jamil S, Hojabrpour P, Duronio V
Biochemical and biophysical research communications 2017 Jan 1;482(1):154-158
Biochemical and biophysical research communications 2017 Jan 1;482(1):154-158
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.
Scott TL, Wicker CA, Suganya R, Dhar B, Pittman T, Horbinski C, Izumi T
Molecular carcinogenesis 2017 Feb;56(2):325-336
Molecular carcinogenesis 2017 Feb;56(2):325-336
Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels.
Li GB, Fu RQ, Shen HM, Zhou J, Hu XY, Liu YX, Li YN, Zhang HW, Liu X, Zhang YH, Huang C, Zhang R, Gao N
Oncotarget 2017 Feb 7;8(6):10359-10374
Oncotarget 2017 Feb 7;8(6):10359-10374
Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.
Fiesel FC, James ED, Hudec R, Springer W
Oncotarget 2017 Dec 5;8(63):106233-106248
Oncotarget 2017 Dec 5;8(63):106233-106248
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J
Nature 2017 Dec 14;552(7684):187-193
Nature 2017 Dec 14;552(7684):187-193
Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.
Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urbé S, Dittmar G, Clague MJ, Mayor U
Molecular neurodegeneration 2017 Apr 11;12(1):29
Molecular neurodegeneration 2017 Apr 11;12(1):29
BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy.
Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, Tan J, Tan Y, Han H, Tian R, Billiar TR, Tao WA, Zhang Z
The Journal of biological chemistry 2016 Oct 7;291(41):21616-21629
The Journal of biological chemistry 2016 Oct 7;291(41):21616-21629
Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, Matsuda N, Oka T
The Journal of biological chemistry 2016 Jul 29;291(31):16162-74
The Journal of biological chemistry 2016 Jul 29;291(31):16162-74
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W, Kim J
Molecular neurodegeneration 2016 Jul 26;11(1):55
Molecular neurodegeneration 2016 Jul 26;11(1):55
Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy.
Ivankovic D, Chau KY, Schapira AH, Gegg ME
Journal of neurochemistry 2016 Jan;136(2):388-402
Journal of neurochemistry 2016 Jan;136(2):388-402
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
Martín-Maestro P, Gargini R, Perry G, Avila J, García-Escudero V
Human molecular genetics 2016 Feb 15;25(4):792-806
Human molecular genetics 2016 Feb 15;25(4):792-806
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T
EMBO reports 2016 Dec;17(12):1844-1856
EMBO reports 2016 Dec;17(12):1844-1856
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.
Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A
Free radical biology & medicine 2016 Dec;101:102-115
Free radical biology & medicine 2016 Dec;101:102-115
Cytoprotection against Hypoxic and/or MPP⁺ Injury: Effect of δ-Opioid Receptor Activation on Caspase 3.
Xu Y, Zhi F, Shao N, Wang R, Yang Y, Xia Y
International journal of molecular sciences 2016 Aug 9;17(8)
International journal of molecular sciences 2016 Aug 9;17(8)
Intracellular pH Modulates Autophagy and Mitophagy.
Berezhnov AV, Soutar MP, Fedotova EI, Frolova MS, Plun-Favreau H, Zinchenko VP, Abramov AY
The Journal of biological chemistry 2016 Apr 15;291(16):8701-8
The Journal of biological chemistry 2016 Apr 15;291(16):8701-8
Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Meissner C, Lorenz H, Hehn B, Lemberg MK
Autophagy 2015;11(9):1484-98
Autophagy 2015;11(9):1484-98
Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Jabir MS, Hopkins L, Ritchie ND, Ullah I, Bayes HK, Li D, Tourlomousis P, Lupton A, Puleston D, Simon AK, Bryant C, Evans TJ
Autophagy 2015;11(1):166-82
Autophagy 2015;11(1):166-82
Pyruvate stimulates mitophagy via PINK1 stabilization.
Park S, Choi SG, Yoo SM, Nah J, Jeong E, Kim H, Jung YK
Cellular signalling 2015 Sep;27(9):1824-30
Cellular signalling 2015 Sep;27(9):1824-30
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation.
Fiesel FC, Ando M, Hudec R, Hill AR, Castanedes-Casey M, Caulfield TR, Moussaud-Lamodière EL, Stankowski JN, Bauer PO, Lorenzo-Betancor O, Ferrer I, Arbelo JM, Siuda J, Chen L, Dawson VL, Dawson TM, Wszolek ZK, Ross OA, Dickson DW, Springer W
EMBO reports 2015 Sep;16(9):1114-30
EMBO reports 2015 Sep;16(9):1114-30
Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.
Peng M, Ostrovsky J, Kwon YJ, Polyak E, Licata J, Tsukikawa M, Marty E, Thomas J, Felix CA, Xiao R, Zhang Z, Gasser DL, Argon Y, Falk MJ
Human molecular genetics 2015 Sep 1;24(17):4829-47
Human molecular genetics 2015 Sep 1;24(17):4829-47
MKK3 deletion improves mitochondrial quality.
Srivastava A, McGinniss J, Wong Y, Shinn AS, Lam TT, Lee PJ, Mannam P
Free radical biology & medicine 2015 Oct;87:373-84
Free radical biology & medicine 2015 Oct;87:373-84
Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.
Rossin F, D'Eletto M, Falasca L, Sepe S, Cocco S, Fimia GM, Campanella M, Mastroberardino PG, Farrace MG, Piacentini M
Cell death and differentiation 2015 Mar;22(3):408-18
Cell death and differentiation 2015 Mar;22(3):408-18
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Yue M, Hinkle KM, Davies P, Trushina E, Fiesel FC, Christenson TA, Schroeder AS, Zhang L, Bowles E, Behrouz B, Lincoln SJ, Beevers JE, Milnerwood AJ, Kurti A, McLean PJ, Fryer JD, Springer W, Dickson DW, Farrer MJ, Melrose HL
Neurobiology of disease 2015 Jun;78:172-95
Neurobiology of disease 2015 Jun;78:172-95
Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.
Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A
EMBO molecular medicine 2015 Jun;7(6):802-18
EMBO molecular medicine 2015 Jun;7(6):802-18
Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy.
Lim GG, Chua DS, Basil AH, Chan HY, Chai C, Arumugam T, Lim KL
The Journal of biological chemistry 2015 Jul 3;290(27):16882-93
The Journal of biological chemistry 2015 Jul 3;290(27):16882-93
Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses.
Lee S, Zhang C, Liu X
The Journal of biological chemistry 2015 Jan 9;290(2):904-17
The Journal of biological chemistry 2015 Jan 9;290(2):904-17
PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402.
Aerts L, Craessaerts K, De Strooper B, Morais VA
The Journal of biological chemistry 2015 Jan 30;290(5):2798-811
The Journal of biological chemistry 2015 Jan 30;290(5):2798-811
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
Bueno M, Lai YC, Romero Y, Brands J, St Croix CM, Kamga C, Corey C, Herazo-Maya JD, Sembrat J, Lee JS, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL
The Journal of clinical investigation 2015 Feb;125(2):521-38
The Journal of clinical investigation 2015 Feb;125(2):521-38
PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.
Choi HK, Choi Y, Kang H, Lim EJ, Park SY, Lee HS, Park JM, Moon J, Kim YJ, Choi I, Joe EH, Choi KC, Yoon HG
Human molecular genetics 2015 Feb 15;24(4):1127-41
Human molecular genetics 2015 Feb 15;24(4):1127-41
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS
The Journal of biological chemistry 2015 Dec 18;290(51):30441-52
The Journal of biological chemistry 2015 Dec 18;290(51):30441-52
CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Palubinsky AM, Stankowski JN, Kale AC, Codreanu SG, Singer RJ, Liebler DC, Stanwood GD, McLaughlin B
Antioxidants & redox signaling 2015 Aug 20;23(6):535-49
Antioxidants & redox signaling 2015 Aug 20;23(6):535-49
Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.
Han JY, Kang MJ, Kim KH, Han PL, Kim HS, Ha JY, Son JH
The Journal of biological chemistry 2015 Apr 17;290(16):10325-35
The Journal of biological chemistry 2015 Apr 17;290(16):10325-35
Phosphorylated ubiquitin chain is the genuine Parkin receptor.
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, Matsuda N
The Journal of cell biology 2015 Apr 13;209(1):111-28
The Journal of cell biology 2015 Apr 13;209(1):111-28
Loss of PINK1 impairs stress-induced autophagy and cell survival.
Parganlija D, Klinkenberg M, Domínguez-Bautista J, Hetzel M, Gispert S, Chimi MA, Dröse S, Mai S, Brandt U, Auburger G, Jendrach M
PloS one 2014;9(4):e95288
PloS one 2014;9(4):e95288
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.
Patil KS, Basak I, Lee S, Abdullah R, Larsen JP, Møller SG
Journal of neuroscience research 2014 Sep;92(9):1167-77
Journal of neuroscience research 2014 Sep;92(9):1167-77
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AM
The Journal of clinical investigation 2014 Sep;124(9):3987-4003
The Journal of clinical investigation 2014 Sep;124(9):3987-4003
Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy.
Grenier K, Kontogiannea M, Fon EA
The Journal of biological chemistry 2014 Oct 24;289(43):29519-30
The Journal of biological chemistry 2014 Oct 24;289(43):29519-30
Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.
Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
The Journal of biological chemistry 2014 Nov 28;289(48):33131-6
The Journal of biological chemistry 2014 Nov 28;289(48):33131-6
Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.
Zhou ZD, Refai FS, Xie SP, Ng SH, Chan CH, Ho PG, Zhang XD, Lim TM, Tan EK
Free radical biology & medicine 2014 Mar;68:220-33
Free radical biology & medicine 2014 Mar;68:220-33
Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A.
Dagda RK, Pien I, Wang R, Zhu J, Wang KZ, Callio J, Banerjee TD, Dagda RY, Chu CT
Journal of neurochemistry 2014 Mar;128(6):864-77
Journal of neurochemistry 2014 Mar;128(6):864-77
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey MA, Kuum M, Liiv M, Anwar T, Eskelinen EL, Kaasik A
Autophagy 2014 Jun;10(6):1105-19
Autophagy 2014 Jun;10(6):1105-19
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, Matsuda N
Nature 2014 Jun 5;510(7503):162-6
Nature 2014 Jun 5;510(7503):162-6
Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression.
Gómez-Sánchez R, Gegg ME, Bravo-San Pedro JM, Niso-Santano M, Alvarez-Erviti L, Pizarro-Estrella E, Gutiérrez-Martín Y, Alvarez-Barrientos A, Fuentes JM, González-Polo RA, Schapira AH
Neurobiology of disease 2014 Feb;62:426-40
Neurobiology of disease 2014 Feb;62:426-40
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
McLelland GL, Soubannier V, Chen CX, McBride HM, Fon EA
The EMBO journal 2014 Feb 18;33(4):282-95
The EMBO journal 2014 Feb 18;33(4):282-95
Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.
Bifsha P, Yang J, Fisher RA, Drouin J
PLoS genetics 2014 Dec;10(12):e1004863
PLoS genetics 2014 Dec;10(12):e1004863
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.
Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y
PLoS genetics 2014 Dec;10(12):e1004861
PLoS genetics 2014 Dec;10(12):e1004861
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B
Circulation 2014 Aug 12;130(7):554-64
Circulation 2014 Aug 12;130(7):554-64
Upregulation of human PINK1 gene expression by NFκB signalling.
Duan X, Tong J, Xu Q, Wu Y, Cai F, Li T, Song W
Molecular brain 2014 Aug 11;7:57
Molecular brain 2014 Aug 11;7:57
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ
The Journal of cell biology 2014 Apr 28;205(2):143-53
The Journal of cell biology 2014 Apr 28;205(2):143-53
The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.
Wood-Kaczmar A, Deas E, Wood NW, Abramov AY
Advances in experimental medicine and biology 2013;961:241-9
Advances in experimental medicine and biology 2013;961:241-9
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart.
Hoshino A, Mita Y, Okawa Y, Ariyoshi M, Iwai-Kanai E, Ueyama T, Ikeda K, Ogata T, Matoba S
Nature communications 2013;4:2308
Nature communications 2013;4:2308
Selective escape of proteins from the mitochondria during mitophagy.
Saita S, Shirane M, Nakayama KI
Nature communications 2013;4:1410
Nature communications 2013;4:1410
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
Murata H, Sakaguchi M, Kataoka K, Huh NH
Molecular biology of the cell 2013 Sep;24(18):2772-84
Molecular biology of the cell 2013 Sep;24(18):2772-84
PINK1 is degraded through the N-end rule pathway.
Yamano K, Youle RJ
Autophagy 2013 Nov 1;9(11):1758-69
Autophagy 2013 Nov 1;9(11):1758-69
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.
Jin SM, Youle RJ
Autophagy 2013 Nov 1;9(11):1750-7
Autophagy 2013 Nov 1;9(11):1750-7
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
Iguchi M, Kujuro Y, Okatsu K, Koyano F, Kosako H, Kimura M, Suzuki N, Uchiyama S, Tanaka K, Matsuda N
The Journal of biological chemistry 2013 Jul 26;288(30):22019-32
The Journal of biological chemistry 2013 Jul 26;288(30):22019-32
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
Narendra DP, Wang C, Youle RJ, Walker JE
Human molecular genetics 2013 Jul 1;22(13):2572-89
Human molecular genetics 2013 Jul 1;22(13):2572-89
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.
Song S, Jang S, Park J, Bang S, Choi S, Kwon KY, Zhuang X, Kim E, Chung J
The Journal of biological chemistry 2013 Feb 22;288(8):5660-72
The Journal of biological chemistry 2013 Feb 22;288(8):5660-72
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
Okatsu K, Uno M, Koyano F, Go E, Kimura M, Oka T, Tanaka K, Matsuda N
The Journal of biological chemistry 2013 Dec 20;288(51):36372-84
The Journal of biological chemistry 2013 Dec 20;288(51):36372-84
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.
Koyano F, Okatsu K, Ishigaki S, Fujioka Y, Kimura M, Sobue G, Tanaka K, Matsuda N
Genes to cells : devoted to molecular & cellular mechanisms 2013 Aug;18(8):672-81
Genes to cells : devoted to molecular & cellular mechanisms 2013 Aug;18(8):672-81
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, Matsuda N
Nature communications 2012;3:1016
Nature communications 2012;3:1016
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.
Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N
Scientific reports 2012;2:1002
Scientific reports 2012;2:1002
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H
The Journal of biological chemistry 2012 Oct 5;287(41):34635-45
The Journal of biological chemistry 2012 Oct 5;287(41):34635-45
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM
Open biology 2012 May;2(5):120080
Open biology 2012 May;2(5):120080
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.
Becker D, Richter J, Tocilescu MA, Przedborski S, Voos W
The Journal of biological chemistry 2012 Jun 29;287(27):22969-87
The Journal of biological chemistry 2012 Jun 29;287(27):22969-87
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy.
Mitsuhashi S, Hatakeyama H, Karahashi M, Koumura T, Nonaka I, Hayashi YK, Noguchi S, Sher RB, Nakagawa Y, Manfredi G, Goto Y, Cox GA, Nishino I
Human molecular genetics 2011 Oct 1;20(19):3841-51
Human molecular genetics 2011 Oct 1;20(19):3841-51
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J, LaVoie MJ, Schwarz TL
Cell 2011 Nov 11;147(4):893-906
Cell 2011 Nov 11;147(4):893-906
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK
Journal of neurochemistry 2011 Jun;117(5):856-67
Journal of neurochemistry 2011 Jun;117(5):856-67
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F
Science (New York, N.Y.) 2010 Sep 3;329(5996):1215-8
Science (New York, N.Y.) 2010 Sep 3;329(5996):1215-8
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
Geisler S, Holmström KM, Treis A, Skujat D, Weber SS, Fiesel FC, Kahle PJ, Springer W
Autophagy 2010 Oct;6(7):871-8
Autophagy 2010 Oct;6(7):871-8
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C
The EMBO journal 2010 Oct 20;29(20):3571-89
The EMBO journal 2010 Oct 20;29(20):3571-89
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS
Human molecular genetics 2010 Oct 1;19(19):3734-46
Human molecular genetics 2010 Oct 1;19(19):3734-46
Structural determinants of PINK1 topology and dual subcellular distribution.
Lin W, Kang UJ
BMC cell biology 2010 Nov 22;11:90
BMC cell biology 2010 Nov 22;11:90
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
Imai Y, Kanao T, Sawada T, Kobayashi Y, Moriwaki Y, Ishida Y, Takeda K, Ichijo H, Lu B, Takahashi R
PLoS genetics 2010 Dec 2;6(12):e1001229
PLoS genetics 2010 Dec 2;6(12):e1001229
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.
Cui M, Tang X, Christian WV, Yoon Y, Tieu K
The Journal of biological chemistry 2010 Apr 9;285(15):11740-52
The Journal of biological chemistry 2010 Apr 9;285(15):11740-52
Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.
Gegg ME, Cooper JM, Schapira AH, Taanman JW
PloS one 2009;4(3):e4756
PloS one 2009;4(3):e4756
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
Liu W, Vives-Bauza C, Acín-Peréz- R, Yamamoto A, Tan Y, Li Y, Magrané J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C
PloS one 2009;4(2):e4597
PloS one 2009;4(2):e4597
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ
Biochemistry 2009 Mar 10;48(9):2045-52
Biochemistry 2009 Mar 10;48(9):2045-52
Characterization of PINK1 processing, stability, and subcellular localization.
Lin W, Kang UJ
Journal of neurochemistry 2008 Jul;106(1):464-74
Journal of neurochemistry 2008 Jul;106(1):464-74
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ
Human molecular genetics 2008 Feb 15;17(4):602-16
Human molecular genetics 2008 Feb 15;17(4):602-16
The kinase domain of mitochondrial PINK1 faces the cytoplasm.
Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 19;105(33):12022-7
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 19;105(33):12022-7
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 7;27(45):12413-8
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 7;27(45):12413-8
Evaluation of the effectiveness and safety of etodolac in prolonged treatment of active osteoarthritis.
Puccetti L, Ciompi ML
International journal of clinical pharmacology research 1991;11(3):143-58
International journal of clinical pharmacology research 1991;11(3):143-58
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