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- References [152]
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- Immunohistochemistry [1]
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- Product number
- BC100-494 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#BC100-494, RRID:AB_10127658
- Product name
- Rabbit Polyclonal PINK1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Human PINK1 Antibody will be reactive to isoform 2.
- Reactivity
- Human, Mouse, Rat, Drosophila, Rabbit
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria.
Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons.
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells.
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α(-/-) Mouse Model.
Chronic treatment with the complex I inhibitor MPP(+) depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6).
Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis.
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway.
Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1.
The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury.
Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons.
USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
Chronic Empaglifozin treatment reduces myocardial infarct size in non-diabetic mice through STAT-3 mediated protection on microvascular endothelial cells and reduction of oxidative stress.
Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease.
Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal.
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.
Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA.
PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.
Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy.
Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo.
Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis.
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy.
PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis.
Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells.
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.
FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells.
Induction of PINK1/Parkin-Mediated Mitophagy.
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing.
Loss of the mitochondrial kinase PINK1 does not alter platelet function.
Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy.
Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury.
Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis.
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
Beclin-1-Dependent Autophagy Protects the Heart During Sepsis.
Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.
RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells.
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Dual role of USP30 in controlling basal pexophagy and mitophagy.
The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death.
Mitochondrial dysfunction activates lysosomal-dependent mitophagy selectively in cancer cells.
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.
Regulation of ER-mitochondria contacts by Parkin via Mfn2.
Mitochondrial Complex I Activity Is Required for Maximal Autophagy.
Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis.
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.
Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.
CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.
Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy.
Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.
The small molecule 2-phenylethynesulfonamide induces covalent modification of p53.
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.
Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels.
Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.
PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation.
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.
BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy.
Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy.
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.
Cytoprotection against Hypoxic and/or MPP⁺ Injury: Effect of δ-Opioid Receptor Activation on Caspase 3.
Intracellular pH Modulates Autophagy and Mitophagy.
Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Pyruvate stimulates mitophagy via PINK1 stabilization.
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation.
Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.
MKK3 deletion improves mitochondrial quality.
Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.
Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy.
Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses.
PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402.
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.
Phosphorylated ubiquitin chain is the genuine Parkin receptor.
Loss of PINK1 impairs stress-induced autophagy and cell survival.
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy.
Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.
Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.
Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A.
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression.
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Upregulation of human PINK1 gene expression by NFκB signalling.
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart.
Selective escape of proteins from the mitochondria during mitophagy.
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
PINK1 is degraded through the N-end rule pathway.
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy.
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
Structural determinants of PINK1 topology and dual subcellular distribution.
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.
Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Characterization of PINK1 processing, stability, and subcellular localization.
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
The kinase domain of mitochondrial PINK1 faces the cytoplasm.
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Evaluation of the effectiveness and safety of etodolac in prolonged treatment of active osteoarthritis.
Ren YZ, Zhang BZ, Zhao XJ, Zhang ZY
Journal of neurochemistry 2020 Sep;154(5):530-546
Journal of neurochemistry 2020 Sep;154(5):530-546
Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons.
Bhupana JN, Huang BT, Liou GG, Calkins MJ, Lin-Chao S
FASEB bioAdvances 2020 Mar;2(3):166-181
FASEB bioAdvances 2020 Mar;2(3):166-181
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.
Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z
Autophagy 2020 Mar;16(3):419-434
Autophagy 2020 Mar;16(3):419-434
FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells.
Park SY, Koh HC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111163
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111163
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α(-/-) Mouse Model.
Sridevi Gurubaran I, Viiri J, Koskela A, Hyttinen JMT, Paterno JJ, Kis G, Antal M, Urtti A, Kauppinen A, Felszeghy S, Kaarniranta K
International journal of molecular sciences 2020 Mar 13;21(6)
International journal of molecular sciences 2020 Mar 13;21(6)
Chronic treatment with the complex I inhibitor MPP(+) depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6).
Verma M, Zhu J, Wang KZQ, Chu CT
The Journal of biological chemistry 2020 Jun 5;295(23):7865-7876
The Journal of biological chemistry 2020 Jun 5;295(23):7865-7876
Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis.
Wang X, Feng L, Xin M, Hao Y, Wang X, Shang P, Zhao M, Hou S, Zhang Y, Xiao Y, Ma D, Feng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110125
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110125
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Park JS, Lee DH, Lee YS, Oh E, Bae KH, Oh KJ, Kim H, Bae SH
Autophagy 2020 Jan;16(1):86-105
Autophagy 2020 Jan;16(1):86-105
IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway.
Riis S, Murray JB, O'Connor R
Cells 2020 Jan 8;9(1)
Cells 2020 Jan 8;9(1)
Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1.
Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T
Scientific reports 2020 Jan 30;10(1):1465
Scientific reports 2020 Jan 30;10(1):1465
The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury.
Huang YF, Gu CJ, Wang Q, Xu L, Chen J, Zhou W, Zhou Z, Zhao SJ, Li LW, Kong FQ, Qian DF, Zhao X, Fan J, Li QQ, Yin GY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2055-2074
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2055-2074
Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Sarkar A, Stellrecht CM, Vangapandu HV, Ayres M, Kaipparettu BA, Park JH, Balakrishnan K, Burks JK, Pandita TK, Hittelman WN, Neelapu SS, Gandhi V
Haematologica 2020 Feb 6;
Haematologica 2020 Feb 6;
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
Franco-Iborra S, Plaza-Zabala A, Montpeyo M, Sebastian D, Vila M, Martinez-Vicente M
Autophagy 2020 Feb 24;:1-18
Autophagy 2020 Feb 24;:1-18
Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons.
Furlong RM, O'Keeffe GW, O'Neill C, Sullivan AM
Neuroscience letters 2020 Feb 16;720:134777
Neuroscience letters 2020 Feb 16;720:134777
USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, Li Y, Balajee AS, Zhao Y
Autophagy 2020 Apr;16(4):724-734
Autophagy 2020 Apr;16(4):724-734
Chronic Empaglifozin treatment reduces myocardial infarct size in non-diabetic mice through STAT-3 mediated protection on microvascular endothelial cells and reduction of oxidative stress.
Nikolaou PE, Efentakis P, Qourah FA, Femminò S, Makridakis M, Kanaki Z, Varela A, Tsoumani M, Davos CH, Dimitriou CA, Tasouli A, Dimitriadis G, Kostomitsopoulos N, Zuurbier CJ, Vlahou A, Klinakis A, Brizzi MF, Iliodromitis EK, Andreadou I
Antioxidants & redox signaling 2020 Apr 16;
Antioxidants & redox signaling 2020 Apr 16;
Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease.
Martín-Maestro P, Gargini R, García E, Simón D, Avila J, García-Escudero V
Journal of Alzheimer's disease : JAD 2019;70(2):525-540
Journal of Alzheimer's disease : JAD 2019;70(2):525-540
Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal.
Park H, Chung KM, An HK, Gim JE, Hong J, Woo H, Cho B, Moon C, Yu SW
Frontiers in molecular neuroscience 2019;12:46
Frontiers in molecular neuroscience 2019;12:46
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, Zhang Z, Shen J, Zhou Y, Zhou W, Gu L, Lu R, Ni Z
Redox biology 2019 Sep;26:101254
Redox biology 2019 Sep;26:101254
Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA.
Tomita K, Takashi Y, Ouchi Y, Kuwahara Y, Igarashi K, Nagasawa T, Nabika H, Kurimasa A, Fukumoto M, Nishitani Y, Sato T
Cancer science 2019 Sep;110(9):2856-2866
Cancer science 2019 Sep;110(9):2856-2866
PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.
Guardia-Laguarta C, Liu Y, Lauritzen KH, Erdjument-Bromage H, Martin B, Swayne TC, Jiang X, Przedborski S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Sep 4;39(36):7074-7085
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Sep 4;39(36):7074-7085
Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy.
Miyai T, Vasanth S, Melangath G, Deshpande N, Kumar V, Benischke AS, Chen Y, Price MO, Price FW Jr, Jurkunas UV
The American journal of pathology 2019 Oct;189(10):2061-2076
The American journal of pathology 2019 Oct;189(10):2061-2076
Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo.
Warnez-Soulie J, Macia M, Lac S, Pecchi E, Bernard M, Bendahan D, Bartoli M, Carrier A, Giannesini B
Physiological reports 2019 May;7(10):e14055
Physiological reports 2019 May;7(10):e14055
Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis.
Cairó M, Campderrós L, Gavaldà-Navarro A, Cereijo R, Delgado-Anglés A, Quesada-López T, Giralt M, Villarroya J, Villarroya F
EMBO reports 2019 May;20(5)
EMBO reports 2019 May;20(5)
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M
Nature communications 2019 May 17;10(1):2205
Nature communications 2019 May 17;10(1):2205
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA
Nature neuroscience 2019 Mar;22(3):401-412
Nature neuroscience 2019 Mar;22(3):401-412
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
Autophagy 2019 Mar;15(3):510-526
Autophagy 2019 Mar;15(3):510-526
Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy.
Eid N, Ito Y, Horibe A, Otsuki Y, Kondo Y
Cells 2019 Mar 25;8(3)
Cells 2019 Mar 25;8(3)
PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis.
Ganzleben I, He GW, Günther C, Prigge ES, Richter K, Rieker RJ, Mougiakakos D, Neurath MF, Becker C
Cellular and molecular life sciences : CMLS 2019 Dec;76(23):4783-4794
Cellular and molecular life sciences : CMLS 2019 Dec;76(23):4783-4794
Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells.
Martín-Maestro P, Sproul A, Martinez H, Paquet D, Gerges M, Noggle S, Starkov AA
Molecular neurobiology 2019 Dec;56(12):8220-8236
Molecular neurobiology 2019 Dec;56(12):8220-8236
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Livingston MJ, Wang J, Zhou J, Wu G, Ganley IG, Hill JA, Yin XM, Dong Z
Autophagy 2019 Dec;15(12):2142-2162
Autophagy 2019 Dec;15(12):2142-2162
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.
Yakhine-Diop SMS, Niso-Santano M, Rodríguez-Arribas M, Gómez-Sánchez R, Martínez-Chacón G, Uribe-Carretero E, Navarro-García JA, Ruiz-Hurtado G, Aiastui A, Cooper JM, López de Munaín A, Bravo-San Pedro JM, González-Polo RA, Fuentes JM
Molecular neurobiology 2019 Apr;56(4):2466-2481
Molecular neurobiology 2019 Apr;56(4):2466-2481
FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells.
Audesse AJ, Dhakal S, Hassell LA, Gardell Z, Nemtsova Y, Webb AE
PLoS genetics 2019 Apr;15(4):e1008097
PLoS genetics 2019 Apr;15(4):e1008097
Induction of PINK1/Parkin-Mediated Mitophagy.
Sato S, Furuya N
Methods in molecular biology (Clifton, N.J.) 2018;1759:9-17
Methods in molecular biology (Clifton, N.J.) 2018;1759:9-17
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.
Tang C, Han H, Yan M, Zhu S, Liu J, Liu Z, He L, Tan J, Liu Y, Liu H, Sun L, Duan S, Peng Y, Liu F, Yin XM, Zhang Z, Dong Z
Autophagy 2018;14(5):880-897
Autophagy 2018;14(5):880-897
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy.
Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S
Autophagy 2018;14(2):311-335
Autophagy 2018;14(2):311-335
Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing.
Xu G, Li T, Chen J, Li C, Zhao H, Yao C, Dong H, Wen K, Wang K, Zhao J, Xia Q, Zhou T, Zhang H, Gao P, Li A, Pan X
Autophagy 2018;14(10):1818-1830
Autophagy 2018;14(10):1818-1830
Loss of the mitochondrial kinase PINK1 does not alter platelet function.
Walsh TG, van den Bosch MTJ, Lewis KE, Williams CM, Poole AW
Scientific reports 2018 Sep 26;8(1):14377
Scientific reports 2018 Sep 26;8(1):14377
Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy.
Sun X, Duan Y, Qin C, Li JC, Duan G, Deng X, Ni J, Cao X, Xiang K, Tian K, Chen CH, Li A, Fang Y
Cell death & disease 2018 Sep 20;9(10):953
Cell death & disease 2018 Sep 20;9(10):953
Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury.
Kim HJ, Joe Y, Rah SY, Kim SK, Park SU, Park J, Kim J, Ryu J, Cho GJ, Surh YJ, Ryter SW, Kim UH, Chung HT
Cell death & disease 2018 Oct 17;9(11):1060
Cell death & disease 2018 Oct 17;9(11):1060
Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis.
Civiletto G, Dogan SA, Cerutti R, Fagiolari G, Moggio M, Lamperti C, Benincá C, Viscomi C, Zeviani M
EMBO molecular medicine 2018 Nov;10(11)
EMBO molecular medicine 2018 Nov;10(11)
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK
Open biology 2018 Nov 7;8(11)
Open biology 2018 Nov 7;8(11)
Beclin-1-Dependent Autophagy Protects the Heart During Sepsis.
Sun Y, Yao X, Zhang QJ, Zhu M, Liu ZP, Ci B, Xie Y, Carlson D, Rothermel BA, Sun Y, Levine B, Hill JA, Wolf SE, Minei JP, Zang QS
Circulation 2018 Nov 13;138(20):2247-2262
Circulation 2018 Nov 13;138(20):2247-2262
Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.
Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, You H, Checler F, Alves da Costa C
Cell death and differentiation 2018 May;25(5):873-884
Cell death and differentiation 2018 May;25(5):873-884
RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells.
Hawk MA, Gorsuch CL, Fagan P, Lee C, Kim SE, Hamann JC, Mason JA, Weigel KJ, Tsegaye MA, Shen L, Shuff S, Zuo J, Hu S, Jiang L, Chapman S, Leevy WM, DeBerardinis RJ, Overholtzer M, Schafer ZT
Nature cell biology 2018 Mar;20(3):272-284
Nature cell biology 2018 Mar;20(3):272-284
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y
Toxicology letters 2018 Jul;291:92-100
Toxicology letters 2018 Jul;291:92-100
Dual role of USP30 in controlling basal pexophagy and mitophagy.
Marcassa E, Kallinos A, Jardine J, Rusilowicz-Jones EV, Martinez A, Kuehl S, Islinger M, Clague MJ, Urbé S
EMBO reports 2018 Jul;19(7)
EMBO reports 2018 Jul;19(7)
The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death.
Yoo L, Chung KC
The Journal of biological chemistry 2018 Jan 26;293(4):1286-1297
The Journal of biological chemistry 2018 Jan 26;293(4):1286-1297
Mitochondrial dysfunction activates lysosomal-dependent mitophagy selectively in cancer cells.
Biel TG, Rao VA
Oncotarget 2018 Jan 2;9(1):995-1011
Oncotarget 2018 Jan 2;9(1):995-1011
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.
Kumar A, Shaha C
Scientific reports 2018 Jan 12;8(1):615
Scientific reports 2018 Jan 12;8(1):615
Regulation of ER-mitochondria contacts by Parkin via Mfn2.
Basso V, Marchesan E, Peggion C, Chakraborty J, von Stockum S, Giacomello M, Ottolini D, Debattisti V, Caicci F, Tasca E, Pegoraro V, Angelini C, Antonini A, Bertoli A, Brini M, Ziviani E
Pharmacological research 2018 Dec;138:43-56
Pharmacological research 2018 Dec;138:43-56
Mitochondrial Complex I Activity Is Required for Maximal Autophagy.
Thomas HE, Zhang Y, Stefely JA, Veiga SR, Thomas G, Kozma SC, Mercer CA
Cell reports 2018 Aug 28;24(9):2404-2417.e8
Cell reports 2018 Aug 28;24(9):2404-2417.e8
Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.
Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Apr;32(4):1880-1890
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Apr;32(4):1880-1890
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis.
Bueno M, Brands J, Voltz L, Fiedler K, Mays B, St Croix C, Sembrat J, Mallampalli RK, Rojas M, Mora AL
Aging cell 2018 Apr;17(2)
Aging cell 2018 Apr;17(2)
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation.
Martín-Maestro P, Gargini R, A Sproul A, García E, Antón LC, Noggle S, Arancio O, Avila J, García-Escudero V
Frontiers in molecular neuroscience 2017;10:291
Frontiers in molecular neuroscience 2017;10:291
Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.
Zhang C, Liu Z, Bunker E, Ramirez A, Lee S, Peng Y, Tan AC, Eckhardt SG, Chapnick DA, Liu X
The Journal of biological chemistry 2017 Sep 8;292(36):15105-15120
The Journal of biological chemistry 2017 Sep 8;292(36):15105-15120
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K
Neurochemistry international 2017 Oct;109:106-116
Neurochemistry international 2017 Oct;109:106-116
Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.
Xiao B, Goh JY, Xiao L, Xian H, Lim KL, Liou YC
The Journal of biological chemistry 2017 Oct 6;292(40):16697-16708
The Journal of biological chemistry 2017 Oct 6;292(40):16697-16708
CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.
Kim H, Ham S, Jo M, Lee GH, Lee YS, Shin JH, Lee Y
International journal of molecular sciences 2017 Oct 3;18(10)
International journal of molecular sciences 2017 Oct 3;18(10)
Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy.
Wettengel J, Reautschnig P, Geisler S, Kahle PJ, Stafforst T
Nucleic acids research 2017 Mar 17;45(5):2797-2808
Nucleic acids research 2017 Mar 17;45(5):2797-2808
Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.
Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, Dudek J
Autophagy 2017 Jan 2;13(1):201-211
Autophagy 2017 Jan 2;13(1):201-211
The small molecule 2-phenylethynesulfonamide induces covalent modification of p53.
Jamil S, Hojabrpour P, Duronio V
Biochemical and biophysical research communications 2017 Jan 1;482(1):154-158
Biochemical and biophysical research communications 2017 Jan 1;482(1):154-158
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.
Scott TL, Wicker CA, Suganya R, Dhar B, Pittman T, Horbinski C, Izumi T
Molecular carcinogenesis 2017 Feb;56(2):325-336
Molecular carcinogenesis 2017 Feb;56(2):325-336
Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels.
Li GB, Fu RQ, Shen HM, Zhou J, Hu XY, Liu YX, Li YN, Zhang HW, Liu X, Zhang YH, Huang C, Zhang R, Gao N
Oncotarget 2017 Feb 7;8(6):10359-10374
Oncotarget 2017 Feb 7;8(6):10359-10374
Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.
Fiesel FC, James ED, Hudec R, Springer W
Oncotarget 2017 Dec 5;8(63):106233-106248
Oncotarget 2017 Dec 5;8(63):106233-106248
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J
Nature 2017 Dec 14;552(7684):187-193
Nature 2017 Dec 14;552(7684):187-193
MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.
Bartolomé A, García-Aguilar A, Asahara SI, Kido Y, Guillén C, Pajvani UB, Benito M
Molecular and cellular biology 2017 Dec 1;37(23)
Molecular and cellular biology 2017 Dec 1;37(23)
PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation.
Gelmetti V, De Rosa P, Torosantucci L, Marini ES, Romagnoli A, Di Rienzo M, Arena G, Vignone D, Fimia GM, Valente EM
Autophagy 2017 Apr 3;13(4):654-669
Autophagy 2017 Apr 3;13(4):654-669
The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.
Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W
Molecular neurodegeneration 2017 Apr 24;12(1):32
Molecular neurodegeneration 2017 Apr 24;12(1):32
Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.
Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urbé S, Dittmar G, Clague MJ, Mayor U
Molecular neurodegeneration 2017 Apr 11;12(1):29
Molecular neurodegeneration 2017 Apr 11;12(1):29
BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy.
Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, Tan J, Tan Y, Han H, Tian R, Billiar TR, Tao WA, Zhang Z
The Journal of biological chemistry 2016 Oct 7;291(41):21616-21629
The Journal of biological chemistry 2016 Oct 7;291(41):21616-21629
Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, Matsuda N, Oka T
The Journal of biological chemistry 2016 Jul 29;291(31):16162-74
The Journal of biological chemistry 2016 Jul 29;291(31):16162-74
miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).
Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W, Kim J
Molecular neurodegeneration 2016 Jul 26;11(1):55
Molecular neurodegeneration 2016 Jul 26;11(1):55
Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy.
Ivankovic D, Chau KY, Schapira AH, Gegg ME
Journal of neurochemistry 2016 Jan;136(2):388-402
Journal of neurochemistry 2016 Jan;136(2):388-402
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
Martín-Maestro P, Gargini R, Perry G, Avila J, García-Escudero V
Human molecular genetics 2016 Feb 15;25(4):792-806
Human molecular genetics 2016 Feb 15;25(4):792-806
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T
EMBO reports 2016 Dec;17(12):1844-1856
EMBO reports 2016 Dec;17(12):1844-1856
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.
Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A
Free radical biology & medicine 2016 Dec;101:102-115
Free radical biology & medicine 2016 Dec;101:102-115
Cytoprotection against Hypoxic and/or MPP⁺ Injury: Effect of δ-Opioid Receptor Activation on Caspase 3.
Xu Y, Zhi F, Shao N, Wang R, Yang Y, Xia Y
International journal of molecular sciences 2016 Aug 9;17(8)
International journal of molecular sciences 2016 Aug 9;17(8)
Intracellular pH Modulates Autophagy and Mitophagy.
Berezhnov AV, Soutar MP, Fedotova EI, Frolova MS, Plun-Favreau H, Zinchenko VP, Abramov AY
The Journal of biological chemistry 2016 Apr 15;291(16):8701-8
The Journal of biological chemistry 2016 Apr 15;291(16):8701-8
Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Meissner C, Lorenz H, Hehn B, Lemberg MK
Autophagy 2015;11(9):1484-98
Autophagy 2015;11(9):1484-98
Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Jabir MS, Hopkins L, Ritchie ND, Ullah I, Bayes HK, Li D, Tourlomousis P, Lupton A, Puleston D, Simon AK, Bryant C, Evans TJ
Autophagy 2015;11(1):166-82
Autophagy 2015;11(1):166-82
Pyruvate stimulates mitophagy via PINK1 stabilization.
Park S, Choi SG, Yoo SM, Nah J, Jeong E, Kim H, Jung YK
Cellular signalling 2015 Sep;27(9):1824-30
Cellular signalling 2015 Sep;27(9):1824-30
(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation.
Fiesel FC, Ando M, Hudec R, Hill AR, Castanedes-Casey M, Caulfield TR, Moussaud-Lamodière EL, Stankowski JN, Bauer PO, Lorenzo-Betancor O, Ferrer I, Arbelo JM, Siuda J, Chen L, Dawson VL, Dawson TM, Wszolek ZK, Ross OA, Dickson DW, Springer W
EMBO reports 2015 Sep;16(9):1114-30
EMBO reports 2015 Sep;16(9):1114-30
Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.
Peng M, Ostrovsky J, Kwon YJ, Polyak E, Licata J, Tsukikawa M, Marty E, Thomas J, Felix CA, Xiao R, Zhang Z, Gasser DL, Argon Y, Falk MJ
Human molecular genetics 2015 Sep 1;24(17):4829-47
Human molecular genetics 2015 Sep 1;24(17):4829-47
MKK3 deletion improves mitochondrial quality.
Srivastava A, McGinniss J, Wong Y, Shinn AS, Lam TT, Lee PJ, Mannam P
Free radical biology & medicine 2015 Oct;87:373-84
Free radical biology & medicine 2015 Oct;87:373-84
Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.
Rossin F, D'Eletto M, Falasca L, Sepe S, Cocco S, Fimia GM, Campanella M, Mastroberardino PG, Farrace MG, Piacentini M
Cell death and differentiation 2015 Mar;22(3):408-18
Cell death and differentiation 2015 Mar;22(3):408-18
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Yue M, Hinkle KM, Davies P, Trushina E, Fiesel FC, Christenson TA, Schroeder AS, Zhang L, Bowles E, Behrouz B, Lincoln SJ, Beevers JE, Milnerwood AJ, Kurti A, McLean PJ, Fryer JD, Springer W, Dickson DW, Farrer MJ, Melrose HL
Neurobiology of disease 2015 Jun;78:172-95
Neurobiology of disease 2015 Jun;78:172-95
Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.
Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A
EMBO molecular medicine 2015 Jun;7(6):802-18
EMBO molecular medicine 2015 Jun;7(6):802-18
Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy.
Lim GG, Chua DS, Basil AH, Chan HY, Chai C, Arumugam T, Lim KL
The Journal of biological chemistry 2015 Jul 3;290(27):16882-93
The Journal of biological chemistry 2015 Jul 3;290(27):16882-93
Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses.
Lee S, Zhang C, Liu X
The Journal of biological chemistry 2015 Jan 9;290(2):904-17
The Journal of biological chemistry 2015 Jan 9;290(2):904-17
PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402.
Aerts L, Craessaerts K, De Strooper B, Morais VA
The Journal of biological chemistry 2015 Jan 30;290(5):2798-811
The Journal of biological chemistry 2015 Jan 30;290(5):2798-811
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
Bueno M, Lai YC, Romero Y, Brands J, St Croix CM, Kamga C, Corey C, Herazo-Maya JD, Sembrat J, Lee JS, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL
The Journal of clinical investigation 2015 Feb;125(2):521-38
The Journal of clinical investigation 2015 Feb;125(2):521-38
PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.
Choi HK, Choi Y, Kang H, Lim EJ, Park SY, Lee HS, Park JM, Moon J, Kim YJ, Choi I, Joe EH, Choi KC, Yoon HG
Human molecular genetics 2015 Feb 15;24(4):1127-41
Human molecular genetics 2015 Feb 15;24(4):1127-41
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS
The Journal of biological chemistry 2015 Dec 18;290(51):30441-52
The Journal of biological chemistry 2015 Dec 18;290(51):30441-52
CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Palubinsky AM, Stankowski JN, Kale AC, Codreanu SG, Singer RJ, Liebler DC, Stanwood GD, McLaughlin B
Antioxidants & redox signaling 2015 Aug 20;23(6):535-49
Antioxidants & redox signaling 2015 Aug 20;23(6):535-49
Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.
Han JY, Kang MJ, Kim KH, Han PL, Kim HS, Ha JY, Son JH
The Journal of biological chemistry 2015 Apr 17;290(16):10325-35
The Journal of biological chemistry 2015 Apr 17;290(16):10325-35
Phosphorylated ubiquitin chain is the genuine Parkin receptor.
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, Matsuda N
The Journal of cell biology 2015 Apr 13;209(1):111-28
The Journal of cell biology 2015 Apr 13;209(1):111-28
Loss of PINK1 impairs stress-induced autophagy and cell survival.
Parganlija D, Klinkenberg M, Domínguez-Bautista J, Hetzel M, Gispert S, Chimi MA, Dröse S, Mai S, Brandt U, Auburger G, Jendrach M
PloS one 2014;9(4):e95288
PloS one 2014;9(4):e95288
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.
Patil KS, Basak I, Lee S, Abdullah R, Larsen JP, Møller SG
Journal of neuroscience research 2014 Sep;92(9):1167-77
Journal of neuroscience research 2014 Sep;92(9):1167-77
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AM
The Journal of clinical investigation 2014 Sep;124(9):3987-4003
The Journal of clinical investigation 2014 Sep;124(9):3987-4003
Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy.
Grenier K, Kontogiannea M, Fon EA
The Journal of biological chemistry 2014 Oct 24;289(43):29519-30
The Journal of biological chemistry 2014 Oct 24;289(43):29519-30
Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.
Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
The Journal of biological chemistry 2014 Nov 28;289(48):33131-6
The Journal of biological chemistry 2014 Nov 28;289(48):33131-6
Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.
Zhou ZD, Refai FS, Xie SP, Ng SH, Chan CH, Ho PG, Zhang XD, Lim TM, Tan EK
Free radical biology & medicine 2014 Mar;68:220-33
Free radical biology & medicine 2014 Mar;68:220-33
Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A.
Dagda RK, Pien I, Wang R, Zhu J, Wang KZ, Callio J, Banerjee TD, Dagda RY, Chu CT
Journal of neurochemistry 2014 Mar;128(6):864-77
Journal of neurochemistry 2014 Mar;128(6):864-77
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria.
Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey MA, Kuum M, Liiv M, Anwar T, Eskelinen EL, Kaasik A
Autophagy 2014 Jun;10(6):1105-19
Autophagy 2014 Jun;10(6):1105-19
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, Matsuda N
Nature 2014 Jun 5;510(7503):162-6
Nature 2014 Jun 5;510(7503):162-6
Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression.
Gómez-Sánchez R, Gegg ME, Bravo-San Pedro JM, Niso-Santano M, Alvarez-Erviti L, Pizarro-Estrella E, Gutiérrez-Martín Y, Alvarez-Barrientos A, Fuentes JM, González-Polo RA, Schapira AH
Neurobiology of disease 2014 Feb;62:426-40
Neurobiology of disease 2014 Feb;62:426-40
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.
Yamano K, Fogel AI, Wang C, van der Bliek AM, Youle RJ
eLife 2014 Feb 25;3:e01612
eLife 2014 Feb 25;3:e01612
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
McLelland GL, Soubannier V, Chen CX, McBride HM, Fon EA
The EMBO journal 2014 Feb 18;33(4):282-95
The EMBO journal 2014 Feb 18;33(4):282-95
Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.
Bifsha P, Yang J, Fisher RA, Drouin J
PLoS genetics 2014 Dec;10(12):e1004863
PLoS genetics 2014 Dec;10(12):e1004863
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.
Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y
PLoS genetics 2014 Dec;10(12):e1004861
PLoS genetics 2014 Dec;10(12):e1004861
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
Fiesel FC, Moussaud-Lamodière EL, Ando M, Springer W
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
Journal of cell science 2014 Aug 15;127(Pt 16):3488-504
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B
Circulation 2014 Aug 12;130(7):554-64
Circulation 2014 Aug 12;130(7):554-64
Upregulation of human PINK1 gene expression by NFκB signalling.
Duan X, Tong J, Xu Q, Wu Y, Cai F, Li T, Song W
Molecular brain 2014 Aug 11;7:57
Molecular brain 2014 Aug 11;7:57
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ
The Journal of cell biology 2014 Apr 28;205(2):143-53
The Journal of cell biology 2014 Apr 28;205(2):143-53
The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.
Wood-Kaczmar A, Deas E, Wood NW, Abramov AY
Advances in experimental medicine and biology 2013;961:241-9
Advances in experimental medicine and biology 2013;961:241-9
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart.
Hoshino A, Mita Y, Okawa Y, Ariyoshi M, Iwai-Kanai E, Ueyama T, Ikeda K, Ogata T, Matoba S
Nature communications 2013;4:2308
Nature communications 2013;4:2308
Selective escape of proteins from the mitochondria during mitophagy.
Saita S, Shirane M, Nakayama KI
Nature communications 2013;4:1410
Nature communications 2013;4:1410
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
Murata H, Sakaguchi M, Kataoka K, Huh NH
Molecular biology of the cell 2013 Sep;24(18):2772-84
Molecular biology of the cell 2013 Sep;24(18):2772-84
PINK1 is degraded through the N-end rule pathway.
Yamano K, Youle RJ
Autophagy 2013 Nov 1;9(11):1758-69
Autophagy 2013 Nov 1;9(11):1758-69
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.
Jin SM, Youle RJ
Autophagy 2013 Nov 1;9(11):1750-7
Autophagy 2013 Nov 1;9(11):1750-7
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
Iguchi M, Kujuro Y, Okatsu K, Koyano F, Kosako H, Kimura M, Suzuki N, Uchiyama S, Tanaka K, Matsuda N
The Journal of biological chemistry 2013 Jul 26;288(30):22019-32
The Journal of biological chemistry 2013 Jul 26;288(30):22019-32
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
Narendra DP, Wang C, Youle RJ, Walker JE
Human molecular genetics 2013 Jul 1;22(13):2572-89
Human molecular genetics 2013 Jul 1;22(13):2572-89
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
Lazarou M, Narendra DP, Jin SM, Tekle E, Banerjee S, Youle RJ
The Journal of cell biology 2013 Jan 21;200(2):163-72
The Journal of cell biology 2013 Jan 21;200(2):163-72
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila.
Song S, Jang S, Park J, Bang S, Choi S, Kwon KY, Zhuang X, Kim E, Chung J
The Journal of biological chemistry 2013 Feb 22;288(8):5660-72
The Journal of biological chemistry 2013 Feb 22;288(8):5660-72
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
Okatsu K, Uno M, Koyano F, Go E, Kimura M, Oka T, Tanaka K, Matsuda N
The Journal of biological chemistry 2013 Dec 20;288(51):36372-84
The Journal of biological chemistry 2013 Dec 20;288(51):36372-84
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons.
Koyano F, Okatsu K, Ishigaki S, Fujioka Y, Kimura M, Sobue G, Tanaka K, Matsuda N
Genes to cells : devoted to molecular & cellular mechanisms 2013 Aug;18(8):672-81
Genes to cells : devoted to molecular & cellular mechanisms 2013 Aug;18(8):672-81
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, Matsuda N
Nature communications 2012;3:1016
Nature communications 2012;3:1016
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.
Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N
Scientific reports 2012;2:1002
Scientific reports 2012;2:1002
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H
The Journal of biological chemistry 2012 Oct 5;287(41):34635-45
The Journal of biological chemistry 2012 Oct 5;287(41):34635-45
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM
Open biology 2012 May;2(5):120080
Open biology 2012 May;2(5):120080
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.
Becker D, Richter J, Tocilescu MA, Przedborski S, Voos W
The Journal of biological chemistry 2012 Jun 29;287(27):22969-87
The Journal of biological chemistry 2012 Jun 29;287(27):22969-87
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy.
Mitsuhashi S, Hatakeyama H, Karahashi M, Koumura T, Nonaka I, Hayashi YK, Noguchi S, Sher RB, Nakagawa Y, Manfredi G, Goto Y, Cox GA, Nishino I
Human molecular genetics 2011 Oct 1;20(19):3841-51
Human molecular genetics 2011 Oct 1;20(19):3841-51
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J, LaVoie MJ, Schwarz TL
Cell 2011 Nov 11;147(4):893-906
Cell 2011 Nov 11;147(4):893-906
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK
Journal of neurochemistry 2011 Jun;117(5):856-67
Journal of neurochemistry 2011 Jun;117(5):856-67
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F
Science (New York, N.Y.) 2010 Sep 3;329(5996):1215-8
Science (New York, N.Y.) 2010 Sep 3;329(5996):1215-8
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
Geisler S, Holmström KM, Treis A, Skujat D, Weber SS, Fiesel FC, Kahle PJ, Springer W
Autophagy 2010 Oct;6(7):871-8
Autophagy 2010 Oct;6(7):871-8
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
Geisler S, Holmström KM, Treis A, Skujat D, Weber SS, Fiesel FC, Kahle PJ, Springer W
Autophagy 2010 Oct;6(7):871-8
Autophagy 2010 Oct;6(7):871-8
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C
The EMBO journal 2010 Oct 20;29(20):3571-89
The EMBO journal 2010 Oct 20;29(20):3571-89
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS
Human molecular genetics 2010 Oct 1;19(19):3734-46
Human molecular genetics 2010 Oct 1;19(19):3734-46
Structural determinants of PINK1 topology and dual subcellular distribution.
Lin W, Kang UJ
BMC cell biology 2010 Nov 22;11:90
BMC cell biology 2010 Nov 22;11:90
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler, Kira M. Holmström, Diana Skujat, Fabienne C. Fiesel, Oliver C. Rothfuss, Philipp J. Kahle, Wolfdieter Springer
Nature Cell Biology 2010 Jan;12(2):119-131
Nature Cell Biology 2010 Jan;12(2):119-131
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
Imai Y, Kanao T, Sawada T, Kobayashi Y, Moriwaki Y, Ishida Y, Takeda K, Ichijo H, Lu B, Takahashi R
PLoS genetics 2010 Dec 2;6(12):e1001229
PLoS genetics 2010 Dec 2;6(12):e1001229
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.
Cui M, Tang X, Christian WV, Yoon Y, Tieu K
The Journal of biological chemistry 2010 Apr 9;285(15):11740-52
The Journal of biological chemistry 2010 Apr 9;285(15):11740-52
Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells.
Gegg ME, Cooper JM, Schapira AH, Taanman JW
PloS one 2009;4(3):e4756
PloS one 2009;4(3):e4756
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
Liu W, Vives-Bauza C, Acín-Peréz- R, Yamamoto A, Tan Y, Li Y, Magrané J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C
PloS one 2009;4(2):e4597
PloS one 2009;4(2):e4597
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ
Biochemistry 2009 Mar 10;48(9):2045-52
Biochemistry 2009 Mar 10;48(9):2045-52
Characterization of PINK1 processing, stability, and subcellular localization.
Lin W, Kang UJ
Journal of neurochemistry 2008 Jul;106(1):464-74
Journal of neurochemistry 2008 Jul;106(1):464-74
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ
Human molecular genetics 2008 Feb 15;17(4):602-16
Human molecular genetics 2008 Feb 15;17(4):602-16
The kinase domain of mitochondrial PINK1 faces the cytoplasm.
Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 19;105(33):12022-7
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 19;105(33):12022-7
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 7;27(45):12413-8
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 7;27(45):12413-8
Evaluation of the effectiveness and safety of etodolac in prolonged treatment of active osteoarthritis.
Puccetti L, Ciompi ML
International journal of clinical pharmacology research 1991;11(3):143-58
International journal of clinical pharmacology research 1991;11(3):143-58
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Supportive validation
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- Western Blot: PINK1 Antibody [BC100-494] - Analysis of PINK1 in HeLa whole cell lysate with and without treatment of 10 uM CCCP. Image courtesy of an anonymous customer review.
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- Western Blot: PINK1 Antibody [BC100-494] - Western blot image of PINK1 antibody (BC100-494) in multiple cells lines. Human HeLa (lane 1), Mouse NIH-3T3 (lane 2), L929 (lane 3) and Rat PC12 (lane 4) whole cell protein were separated by SDS-PAGE on a 7.5% polyacrylamide gel. Protein was transferred to PVDF membrane and probed with 2 ug/ml BC100-494 in 1% BSA and detected with an HRP-conjugated anti-rabbit secondary antibody using chemiluminescence. Observed molecular weight ~55 kDa (arrowhead).
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- Western Blot: PINK1 Antibody [BC100-494] - Whole cell protein from HeLa cells treated without or with valinomycin (1 uM for 24h) as indicated were separated by SDS-PAGE on a 7.5% polyacrylamide gel. Protein was transferred to PVDF membrane and probed with 1.0 ug/ml BC100-494 in 1% BSA and detected with an HRP-conjugated anti-rabbit secondary antibody using chemiluminescence. Observed molecular weight ~55 kDa in the treated sample(arrowhead).
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- Western Blot: PINK1 Antibody [BC100-494] - Analysis of PINK1 in mouse liver and hypatocytes using PINK1 antibody. Image from verified customer review. Observed molecular weight ~55 kDa.
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- Western Blot: PINK1 Antibody [BC100-494] - WB analysis of lysates derived from hTERT-RPE1 cells transfected with non-targeting (NT1) or PINK1 targeting siRNA for 72 h. 20 uG were loaded. Image from verified customer review. Observed molecular weight ~62 kDa.
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- Western Blot: PINK1 Antibody [BC100-494] - Alteration of mitochondria and PD associated proteins in SH-SY5Y cells with telomere removal by CRISPR-Cas9. Representative Western blot of PGC-1alpha, NRF1, and PINK1 in SH-SY5Y cells transfected with either gTel or gCont (72 h). beta-actin served as a loading control. Image collected and cropped by CiteAb from the following publication (http://www.mdpi.com/1422-0067/18/10/2093), licensed under a CC-BY licence.
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- Western Blot: PINK1 Antibody [BC100-494] - Pathogenic mutants of Parkin are subjected to Ser65 phosphorylation. Phos-tag Western blotting for Parkin and Western blotting for PINK1 were performed using Parkin WT and a series of pathogenic mutants. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep01002) licensed under a CC-BY licence.
Supportive validation
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- Immunohistochemistry-Paraffin: PINK1 Antibody [BC100-494] - Rabbit heart tissue. Image from verified customer review.
