CABT-B11957

antibody from Creative Diagnostics

Targeting: GZMA CTLA3, HFSP

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-B11957

Provider

Creative Diagnostics

Product name

Human anti-Human GZMA recombinant monoclonal antibody, clone SFB273

Antibody type

Monoclonal

Description

It recognozes granzyme A, a member of serine protease family expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells. Granzyme A is a homodimeric protease and is one of the five granzymes expressed by humans. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. NK cells and \u03b3\u03b4 T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells. Granzymes other than granzyme B, exert relatively weaker apoptotic activity. Additional reported functions of granzyme A include, to facilitate the migration of T and NK cells and induction of cytokine secretion. Additional information: It displays negligible binding to Fc receptors.

Reactivity

Human

Host

Human

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

SFB273

Vial size

100 _g in 100 _L

Storage

Store protected from light at 2ÿ8 °C. Do not freeze.