BS7843

antibody from Bioworld Technology, Inc
Targeting: PROCR CCD41, CD201, EPCR
Provider product page for BS7843
Western blot
Immunohistochemistry

Antibody data

Product number
BS7843 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PROCR polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PROCR.
Description
Thrombomodulin (TM) is an endothelial specific receptor that forms a complex with Thrombin, a protein with procoagulant, inflammatory and anticoagu-lant effects. The TM/Thrombin complex activates Protein C (PC) to generate activated Protein C (APC) and initiate the APC anticoagulant pathway. APC attenuates Thrombin formation through the inactivation, by limited proteolysis, of two significant cofactors of blood clot formation, Factor Va and Factor VIIIa. This process is augmented by the activity of the endothelial cell Protein C receptor (EPCR), which binds both PC and APC with high affinity. The EPCR gene maps to human chromosome 20q11.2 and encodes an anticoagulant that is preferentially expressed on large blood vessel endothelium in the heart and lung with some expression in capillaries in the lung and skin. EPCR, also designated CCD41 in mouse, is a member of the major histocompatibility complex and displays significant homology to CD1. Soluble plasma EPCR is thought to inhibit the membrane-bound EPCR activation of the APC pathway.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PROCR protein structure - BS7843 shown in red.