RBAK

This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]

Description

RB associated KRAB zinc finger

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

7 (5045821 - 5069487)

Ensembl ID

ENSG00000146587  (ver. 103.38)

Orthologs

Mouse Rbak: ENSMUSG00000061898

UniProt

Q9NYW8

neXtProt

NX_Q9NYW8

Human splice variants
Mouse splice variants

Protein structure