BS4651

antibody from Bioworld Technology, Inc
Targeting: ARAF ARAF1
Provider product page for BS4651
Western blot
Immunohistochemistry

Antibody data

Product number
BS4651 - Provider product page
Provider
Bioworld Technology, Inc
Product name
A Raf (phospho Y302) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human A-Raf around the phosphorylation site of Tyrosine 302.
Description
Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. A-Raf, a second member of the Raf gene family of serine/ threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of A-Raf is found at highest levels in urogenital tissues and kidney and at lowest level in brain tissue.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ARAF protein structure - BS4651 shown in red.