DNAJB5

This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]

Description

DnaJ heat shock protein family (Hsp40) member B5

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (34989641 - 34998900)

Ensembl ID

ENSG00000137094  (ver. 103.38)

Orthologs

Mouse Dnajb5: ENSMUSG00000036052

UniProt

O75953

neXtProt

NX_O75953

Human splice variants
Mouse splice variants

Protein structure